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HSBC said the bank's performance in Europe and some parts of the United States was "unacceptable" as third-quarter profit declines.
Analyst estimates were missing, with Europe's largest bank, $ 4.8 billion (£ 3.8 billion), a 18{7be40b84a6a43fc4fae13304fce9a2695859798abfc41afd127b9f8b21c5f9c5} drop in pre-tax profit for three months from September.
In the statement, the bank also warned against a "challenging" environment.
HSBC is exploring uncertainties due to Brexit, the US-China trade war and Hong Kong's ongoing instability.
After the earnings release, shares fell 2.7 percent in Hong Kong trading.
Noel Quinn, who took office as acting chief of HSBC after John Flint's shock start in August, praised his performance in Asia but criticized other regions.
Banks make the most money in Asia.
Quinn said, “Some of our business, especially in Asia, has survived in difficult environments in the third quarter.
"However, in some regions, business activity was not allowed, mainly in continental Europe, in the UK non-payment banks and in the United States.
Quinn said the previous plan to improve the performance of these businesses is no longer sufficient and "accelerates the renovation plan."
The bank also said its sales environment was "more challenging" than in the first half and predicted revenue growth "softer" than previously anticipated.
It also warned against "significant charges" if the background would get worse, including situations related to restructuring in the fourth quarter.
Asian performance
HSBC warned that profits would be generated by China's slowing economy earlier this year, but in the third quarter, a wider area affected bank profitability.
The bank said Asia's pretax profit rose 4 percent to $ 4.7 billion during this period, referring to Hong Kong's "elasticity".
The region that has raised concerns about the economic impact and reputation of the Asian financial hub has been insecure for months.