Caesarean section baby has different intestinal bacteria, microbiome study | Social

Babies born at a caesarean site have different intestinal bacteria than vaginally secreted intestinal bacteria, and to date the most comprehensive study of microbial groups for babies has been found.

According to the study, qualitatively born babies account for most of the initial dose of bacteria from their mothers, while C-section babies have more bugs associated with the hospital environment, including strains that show antimicrobial resistance. These results can explain the high prevalence of asthma, allergies and other immune conditions in babies born with caesarean section.

Nigel Field, senior author at the University College London, said, “How the immune system works in our lives can be influenced by our first interaction with bacteria. “If there are differences in long-term health outcomes with different patterns, [bacteria]Tells you something important about your health

Previously, it was thought that the baby's microflora could be formed by bacteria that swallow on the birth canal. However, recent studies have shown that the microbial population of vaginal delivery newborns is not from vaginal bacteria, but from the mother's intestines. Probably born at birth.

This raises the question of wiping babies born in the C-section with vaginal bacteria immediately after birth.

"Villing sowing is very controversial," said Peter Brocklehurst, professor of women's health and co-author of the University of Birmingham. "We did not find any biological evidence that it would be effective."

The baby is sterile when in the womb, but as soon as he is exposed to the outside world, he begins to ingest bacteria, quickly colonizing the intestines. The difference between the two groups disappeared from six months to nine months.

But scientists can become the “temperature-regulated” moment of the immune system when they are first exposed to bacteria at birth, and define their sensitivity and how the bacteria react.

Scientists have not yet revealed the exact mechanism by which initial exposure affects immune activity, which must be addressed before it actually affects clinical research.

Brocklehurst said it would be undesirable for parents to try to administer maternal enteric bacteria to babies with cesarean section.

"I'm very concerned about intentionally introducing them artificially," he said.

In the future, however, it may be routine to administer a certain amount of bacteria to a baby born through caesarean section.

Experts also said the findings should not surprise women who have had or planned a cesarean section. "In many cases, cesarean section is a life-saving procedure and can be the right choice for women and her babies," said Alison Wright, a lost gynecologist and gynecologist.

"The exact role of microbial communities in newborns and the factors that can change them are not yet clear, so I do not think women in this study should not have a cesarean section.

The study also suggested that antibiotics, usually administered before cesarean section, play an important role in the formation of baby microbiomes. Breastfeeding affected the gut bacteria but played a smaller role, the study said.

The study, published in Nature, took seven years and included taking 1,679 stool samples from nearly 600 babies and 175 mothers. They were posted to the Sanger Institute in Cambridgeshire and entered the freezer.

The team wants to expand the research to include a larger number of babies, including those born at home. In addition, we want to see in more detail how long a hospital bug with antimicrobial resistance lasts, and how this poses a danger for babies born through cesarean section.

Professor Andrew Shenan, an obstetrics and gynecologist at King's College London, London, said, “This important study confirms that the way we give birth will change our microbial population in the first year of life. By caesarean delivery, bacteria-like bacteria are reduced in the baby's intestines.

“This is not known to be harmful and mothers who need a cesarean section should not be surprised. In long-term health conditions, we need to evaluate the additional effects of this. ”



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